FLIP anticorps (AA 449-465)

N° du produit ABIN1886881

Cet anticorps Lapin Polyclonal détecte spécifiquement FLIP dans WB, ELISA et ICC. Il présente une réactivité envers Souris.

Aperçu rapide pour FLIP anticorps (AA 449-465) (ABIN1886881)

Antigène: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLIP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-FLIP anticorps

Épitope: AA 449-465

Specificité: FLIP has short form (FLIPS) and long form (FLIPL) and antibody recognizes the FLIPL only.

Purification: Purified by DEAE column

Immunogène: Peptide corresponding to amino acids 449 to 465 of mouse FLIPL/CASHa.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur FLIP

Antigène: FLIP (CFLAR) (CASP8 and FADD-Like Apoptosis Regulator (CFLAR))

Autre désignation: FLIP

Sujet: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED-3 protease family.Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family.FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP respectively.The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH, CLARP and MRIT.FLIP contains two death effector domains (DEDs) and a caspase-like domain.FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors CD95, DR3, TRAIL-R and TNFR1.
Synonyms: I-FLICE

Poids moléculaire: 55 kDa

NCBI Accession: NP_997536

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development